The "all-purpose antioxidant" - Thioctic Acid / lipoic acid

Thioctic Acid, also known as α-lipoic acid (ALA), is a vitamin-like endogenous disulfide compound in the human body, which is present in mitochondria and can eliminate free radicals that accelerate aging and cause disease.

Thioctic Acid is an endogenous antioxidant that can regenerate endogenous antioxidants, which can be absorbed into cells through the intestines in the body, and has the characteristics of both fat-soluble and water-soluble, and can pass through the whole body unhindered, reaching any cell site, providing comprehensive efficacy for the human body, and is known as a "universal antioxidant".

Thioctic Acid acid has super antioxidant ability, can remove the active oxygen species that cause skin aging, and because it is smaller than the molecule of vitamin E, it is both water-soluble and fat-soluble, so it is well absorbed.

Especially effective for dark circles, wrinkles and spots, plus strengthen the metabolic function will improve the body's blood circulation, improve the dullness of the skin, and reduce the appearance of pores. Therefore, Thioctic Acid is also the No. 1 anti-aging "weapon" in the United States, which is on par with Q10.

Sufficient Thioctic Acid can minimize the damage of ultraviolet rays to the skin from the body, and can also alleviate the skin damage caused by aging and generate new skin, keeping the skin moisturized.

The principle of the efficacy of Thioctic Acid / lipoic acid:

Zinc sulfate directly makes cadmium lose its toxicity and protect cells by chelating metal ions.

Thioctic Acid acid reduces free radical production by scavenging cadmium content.

In addition, it can regenerate the effect of other antioxidants, scavenge the free radicals that have been produced, and protect cells from damage.

Thioctic Acid / lipoic acid has the effect of chelating metal ions, such as iron, copper, mercury, cadmium, etc., thereby inhibiting the free radical reaction catalyzed by metal ions, reducing the peroxidation of lipids and other macromolecules caused by metal ions, reducing inflammatory reactions, and reducing tissue damage.

In animal models, it has been shown to protect against arsenic poisoning and can attenuate hepatotoxicity after chromium poisoning.

In vitro tests, it was also found that mercury ions could be chelated from kidney sections.

With the increase of α-LA dose, the number of cells gradually increased, the morphology was basically normal, most of the cells were polygonal or short spindle-shaped, the intercellular space was significantly reduced, the intercellular connection was tighter, and the cell boundary was gradually clear, which was closer and closer to the normal control group. These results show that α-LA has a good repair effect on cell morphology and cell junction caused by oxidative damage.

With the increase of α-LA dose, the apoptosis rate decreases. These results show that α-LA has a reparative effect on apoptosis caused by oxidative damage to hydrogen peroxide, and even high concentrations of α-LA can promote cell proliferation.

Thioctic Acid / lipoic acid has the effect of scavenging free radicals, and its ability to scavenge free radicals is more than 100 times that of vitamin C, especially suitable for anti-aging products; Thioctic Acid acid has the effect of chelating metal ions, can bind to copper ions in tyrosinase, is a competitive inhibitor of tyrosinase, and has a good whitening effect.

However, ordinary Thioctic Acid / lipoic acid has the problems of low solubility, poor stability and significant odor, which limits its application in cosmetics.

The combination of Thioctic Acid / lipoic acid and cyclodextrin into lipoic acid inclusion can improve the deficiency of Thioctic Acid / lipoic acid.

BeriCos ALA-Nano is a solution to the application problems of Thioctic Acid / lipoic acid applied by Beri Pharma's® molecular capsule technology, which has the characteristics of good solubility, high stability and low odor.

Test Method: Comparative test of BeriCos® ALA-Nano and Thioctic Acid / lipoic acid at 100°C (100% lipoic acid content at 0 hours) and the results are as follows:

The results showed that BeriCos® ALA-Nano could significantly improve the utilization rate and stability of Thioctic Acid / lipoic acid.

On the left is Nano inclusion complex α-lipoic acid, and on the right is Thioctic Acid / lipoic acid。

The solubility of BeriCos® ALA-Nano in room temperature water is more than 20% (the effective concentration of Thioctic Acid / lipoic acid > 2.6%), and the solubility is significantly higher than that of Thioctic Acid / lipoic acid (0.06%).