What is the correct structure of Azelamide MEA? Revealed on today

1. As a derivative of azelaic acid, it plays a role in the production of azelaic acid when encountering the skin. It can prevent hyperkeratosis, and can have good effects in whitening and lightening spots, antibacterial, acne and oil control.

2. It has good water solubility and has the same biological activity as azelaic acid, but it does not have the inherent shortcomings of azelaic acid that is insoluble in water/oil, destroys the emulsification system, is difficult to exert the effect, and has high irritation, so it is often used as a substitute for azelaic acid in cosmetics.

3. A new type of sebum balancer, suitable for the care of oily and seborrheic skin. 100% monomer, non-itchy, non-irritating, non-red, irritating or overly dry skin.

4. Its solubility is better, and less addition (0.2~2.35% addition) can achieve the effect of azelaic acid (10~20% addition).

Regarding the chemical structure of Azelamide MEA, our company has consulted a large number of literature and data, including the CIR safety assessment report "Safety Assessment of Ethanolamides as Used in Cosmetics", the EU CosIng cosmetic ingredient database, Chemspider and chemicalbook websites, etc., Azelamide MEA) is as follows:

In addition to this reaction, it is also accompanied by side reactions: (1) esterification reaction to generate ethanolamine azelaate; (2) Azelaic acid reacts with excess ethanolamine to form azelayldiethanolamine (alemidatri).

Our company has carried out mass spectrometry and nuclear magnetic resonance detection and analysis of the product, and the results are fully in line with the spectral characteristics of azelamide MEA, which can confirm that our azelamide MEA is the correct structure.

Most of the competing products on the market have incorrect structures, and they are actually alamitri (not in the "Catalogue of Used Cosmetics"), which is the reaction product of azelaic acid and 2 parts of ethanolamine.

Many peers in the market sell alemidamide and azelamidamide MEA as one product, but in fact, they are two products with different structures, which are very different. In terms of production cost, alsemitra is only one step of the process, and the reaction and control are simple, so the cost is low, and the price on the market is also low.

The M1 peak (232.26, hydrogenation peak) and M 23 peak (254.24, sodium added peak) of Azelamide MEA were seen from the mass spectra of BeriCos® Azelamide MEA, and its molecular weight was determined to be 231, which was consistent with the mass spectral characteristics of Azelamide MEA.

From the NMR spectrum of BeriCos® Azelamide MEA, it can be seen that there is 1 amide active hydrogen, and the total hydrogen number is 21 (note: there is no peak of hydroxyl and carboxyl active hydrogen), which is in line with the characteristics of azelamide MEA nuclear magnetic spectrum.

In order to further confirm the structure, we also conducted the same test on the azeladiamide MEAs of several competitors, and the results were consistent with the spectral characteristics of alemidamid, confirming that the azeladiamide MEAs sold by the company were structurally incorrect.

From the above spectrum, the MEA M 1 peak (275.27, hydrogenation peak) and M 23 peak (297.24, sodium added peak) were obvious, and its molecular weight was 274, which was consistent with the mass spectral characteristics of alemitira.

From the above NMR spectra, it can be seen that the total hydrogen number is 26, including 2 amide active hydrogen and 1 hydroxyl active hydrogen (note, the hydroxyl active hydrogen exchange rate is faster, and the integral area decreases), which is consistent with the NMR spectral characteristics of alemitrol.

It is not easy to synthesize the correct structure of azelamide MEA, although the overall process and impurity control required by the production process is more difficult, but we must ensure that the raw materials produced are of the correct structure and are of acceptable quality, rather than selling dog meat on the head of a sheep.

Insist on doing the right thing, and supply high-quality raw materials to the market. This is also the entrepreneurial spirit of Beri Pharma.