Anti-dandruff Expert | Zinc pyrithione

First, let's look at some common anti-dandruff agents on the market.

2、 Climbazole (Gamboge): It has broad-spectrum antibacterial properties and is mainly used in anti-itching and anti-dandruff conditioning shampoos and hair conditioners. It can also be used in antibacterial soaps, shower gels, medicated toothpastes, and mouthwashes.

3、 Zinc Pyrithione (ZPT): It has strong antifungal properties, effectively killing Malassezia globosa, which causes dandruff. However, shampoos containing ZPT require preservatives and have a maximum allowable concentration of 1.5%. Although harmless to humans, it is highly harmful to the environment. The EU has banned this ingredient since 2022.

4、 Octopirox (OCT): By killing bacteria and antioxidation, it fundamentally blocks the external channels of dandruff production, effectively curing dandruff and stopping itching, rather than temporarily eliminating dandruff through degreasing. This is one of the reasons why OCT's anti-dandruff and anti-itching performance is superior to similar products.

6、 Selenium Sulfide: It inhibits Malassezia globosa, which causes dandruff. Its anti-dandruff effect is only temporary and cannot cure it. It is also quite irritating, similar to antibiotics. It is effective quickly but should not be abused. It should not be used on inflamed, eroded, or oozing skin.

7、 己脒定二(羟乙基磺酸)盐: It is a water-soluble, broad-spectrum antibacterial and antimicrobial cationic substance with high bactericidal and bacteriostatic effects against various Gram-positive and Gram-negative bacteria, as well as various molds and yeasts, and is very mild.

We are introducing 己脒定二(羟乙基磺酸)盐

It is a new type of anti-dandruff and anti-itching agent, a broad-spectrum bacteriostatic and bactericidal agent against bacteria, fungi, and yeasts. It is increasingly used in the cosmetics industry and has excellent anti-acne, oil control, anti-irritation, and anti-dandruff effects.

Our scalp keratinocytes complete a replacement and renewal cycle approximately every 28 days. During this metabolic process, a large amount of old and waste keratin is shed, commonly known as dandruff. Dandruff is common, but when it exceeds the physiological range and is secreted in large quantities, it forms "seborrheic dermatitis," which is usually closely related to "Malassezia."

Malassezia is a single-celled fungus belonging to the yeast family. It usually feeds on fatty acids decomposed from sebum and simultaneously metabolizes a large amount of free fatty acids, including oleic acid. Oleic acid interferes with the metabolism of scalp keratin, leading to the production of a large amount of dandruff.

己脒定二（羟乙基磺酸）盐 is a new type of anti-dandruff and anti-itching agent that has a very strong killing effect on Malassezia globosa (Pityrosporum ovale), which causes dandruff, due to its unique structure.

1. The minimum inhibitory concentration (MIC) against Malassezia is 12.5 μg/ml, and the minimum bactericidal concentration (MBC) is 100 μg/ml;

2. Its cationic nature causes adsorption to the hair, which is more conducive to enhancing and prolonging the anti-dandruff effect, a characteristic not possessed by other anti-dandruff agents;

3. Dermatological clinical studies have shown that shampoos containing 0.1% 己脒定二（羟乙基磺酸）盐 significantly reduce Malassezia in the scalp area per unit area compared to control shampoos. As the density of Malassezia decreases, the severity of dandruff also improves significantly;

4. Convenient and easy to use, water-soluble, non-settling, no need for suspension;

5. Does not cause discoloration;

6. Safe and mild, essentially non-irritating to the eyes, and can remain on the skin and scalp;

7. Widely applicable, in addition to shampoos and hair care products, it can also be used in spray products.

Efficacy Feature 2: Effective Acne and Blackhead Removal

In addition to its use in anti-dandruff products, the zinc pyrithione (hydroxyethyl sulfonate) salt, due to its unique antibacterial properties, exhibits highly effective antimicrobial activity against bacteria that cause acne (Cutibacterium acnes and Staphylococcus epidermidis), anaerobic bacteria, and fungi associated with acne, indirectly providing anti-inflammatory effects.

It has antimicrobial activity against specific strains such as Cutibacterium acnes and can also inhibit the lipase activity of Cutibacterium acnes.

Antimicrobial activity is not affected by the presence of large amounts of skin secretions, especially in oily or acne-prone skin.