Nano solid dispersant - Coenzyme Q10
Release time:2025-08-07
About Coenzyme Q10
Source of Coenzyme Q10
Coenzyme Q10 is a lipophilic molecule composed of an isoprenoid side chain and a redox-active center (quinone structure).
Due to its lipophilicity, Coenzyme Q10 easily penetrates cell membranes to reach the inside of cells, and is particularly easily enriched in the inner mitochondrial membrane, where it plays an important role as an electron carrier in the electron transport chain.
Principle of Coenzyme Q10
Reactive oxygen species (ROS) are more easily produced after ultraviolet exposure and mitochondrial DNA (MT DNA) mutations or deletions, stimulating the expression of collagen and elastin degrading enzymes (i.e., matrix metalloproteinases), leading to skin sagging and aging.
To eliminate ROS, our mitochondria contain scavenging enzymes such as superoxide dismutase and catalase, as well as various antioxidants. One important antioxidant is Coenzyme Q10 (Co-Q10), also known as ubiquinone.
Efficacy of Coenzyme Q10
① Inhibiting melanin synthesis
Coenzyme Q10 can penetrate the skin, reduce reactive oxygen species free radicals produced by UVA induction, improve the skin's resistance to ultraviolet rays, and has a very good whitening effect.
②Lightening wrinkles
After the age of 20, the body's Coenzyme Q10 reaches its peak, and then it shows a downward trend. At this time, it is necessary to supplement Coenzyme Q10 from the outside. Coenzyme Q10 can promote collagen production, keeping the skin smooth and full.
③ Repair and prevent skin photodamage
With the increase of Coenzyme Q10 concentration, the number and thickness of epidermal cells will also increase, forming a natural skin screen that can resist ultraviolet damage.
Coenzyme Q10 Nano Solid Dispersion
Product Information
Coenzyme Q10 Nano Solid Dispersion
Appearance: Light yellow-orange powder
Odor: Slight special odor
Solubility: Water-soluble
Z-average diameter (1% aqueous solution): ≤350nm
Coenzyme Q10 content: 11%
What is nano solid dispersion technology?
Solid Dispersion (SD) technology refers to the pharmaceutical technology used to prepare solid dispersions (systems referring to the dispersion system formed by uniformly dispersing poorly soluble drugs in a solid carrier substance in a molecular, colloidal, or microcrystalline state ).
Advantages of Nano Solid Dispersion
Advantages of Coenzyme Q10 Nano Solid Dispersion
Coenzyme Q10 is an almost completely water-insoluble ingredient and is sensitive to light and heat, which limits its application.
BoRui Pharmaceutical uses nano solid dispersion, a new dosage form, to solve the problems of solubility and stability of Coenzyme Q10.
1
In Coenzyme Q10 solid dispersion, Coenzyme Q10 is dispersed in the carrier in an amorphous state with a particle size of ≤350 nm, and spontaneously forms a nanoemulsion with an average particle size of about 300 nm after dissolving in water, significantly improving the water solubility of Coenzyme Q10 。
2
Coenzyme Q10 solid dispersion can significantly improve the stability of Coenzyme Q10 , Coenzyme Q10 solid dispersion and prototype Coenzyme Q10 were used for stability tests under different conditions, and the residual rate of Coenzyme Q10 was detected after the experiment. The results showed that under the solid dispersion dosage form, the residual rate of Coenzyme Q10 was higher than that of the prototype, greatly improving the stability of its products 。
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BERI PHARMA CO., LTD.
Beri Pharma Co., Ltd. is a technology-based enterprise specializing in the research and production of raw materials and preparations for big health (pharmaceuticals, health products), as well as cosmetic raw materials.
Address: No. 2, Nanhua 4th Road, Nanshui Town, Gaolan Port Economic Zone, Zhuhai
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